Top Flea and Tick Topical Treatments for Dogs

The best Dog Flea & Tick Topical Treatments includes PetArmor Plus Flea & Tick Treatment [3 Doses], FRONTLINE Plus Flea & Tick Treatment (3 Pack), K9 Advantix II XL Dog Flea & Tick Treatment and many others as mentioned below.

1

PetArmor Plus Flea & Tick Treatment [3 Doses]

  • Waterproof formula for lasting protection.
  • Kills fleas, ticks, and chewing lice.
  • Fast-acting; starts working within 24 hours.
  • Prevents re-infestation by breaking flea life cycle.
  • Three doses provide up to three months' protection.
  • Vet-quality ingredients ensure reliable effectiveness.
  • Easy to apply topical treatment for dogs.
  • Average Rating out of 5:
  • Price Range: $24.93
  • Size: 3 Count
  • Color: Pack of 3
2

FRONTLINE Plus Flea & Tick Treatment (3 Pack)

  • Fast-acting flea and tick protection for dogs.
  • Waterproof formula for lasting effectiveness.
  • Kills fleas, eggs, larvae, and ticks.
  • Protects against Lyme disease transmission.
  • Easy monthly application for convenience.
  • Safe for puppies over eight weeks old.
  • Available for both dogs and cats.
  • Average Rating out of 5:
  • Price Range: $39.98
  • Size: 3 Count
  • Color: Purple Box
3

K9 Advantix II XL Dog Flea & Tick Treatment

  • Vet-recommended flea and tick protection for dogs.
  • Effective on dogs over 55 lbs. weight.
  • Kills fleas within 12 hours of application.
  • Repels mosquitoes, biting flies, and lice.
  • Easy topical application; fragrance-free formula.
  • Waterproof after 24 hours for lasting protection.
  • No prescription needed for purchase.
  • Average Rating out of 5:
  • Price Range: $31.00
  • Size: 2 Pack
  • Color: Extra-Large Dog only
4

FRONTLINE Plus Flea & Tick Treatment (3 Pack)

  • Effective flea and tick protection for dogs.
  • Fast-acting and waterproof topical treatment.
  • Kills fleas, flea eggs, larvae, and ticks.
  • Protects against Lyme disease transmission.
  • Easy monthly application for continuous protection.
  • Safe for puppies over eight weeks old.
  • Available for both dogs and cats.
  • Average Rating out of 5:
  • Price Range: $39.98
  • Size: 3 count
  • Color: Orange Box
5

K9 Advantix II Large Dog Flea & Tick Treatment

  • Vet-recommended for effective flea and tick control.
  • Protects dogs 21-55 lbs from pests.
  • Kills fleas within 12 hours of application.
  • Repels mosquitoes, biting flies, and lice.
  • Easy-to-apply topical treatment, fragrance-free.
  • Waterproof after 24 hours of application.
  • No prescription required for purchase.
  • Average Rating out of 5:
  • Price Range: $53.99
6

TevraPet Activate II Flea Treatment [4 Count]

  • Fast-acting flea and tick prevention for dogs.
  • Four monthly doses for continuous protection.
  • Effective for extra large dogs over 55 lbs.
  • Breaks flea life cycle, preventing infestations.
  • Easy application at the base of the neck.
  • Waterproof formula ensures lasting effectiveness.
  • Made in America with guaranteed results.
  • Average Rating out of 5:
  • Price Range: $24.27
  • Size: X-Large 55+ lbs
  • Color: Clear
7

Vet's Best Flea and Tick Home Spray [32 oz]

  • Eliminates fleas, ticks, and mosquitoes effectively.
  • Gentle on dogs 12 weeks or older.
  • No stains or residue on surfaces.
  • Made with certified natural plant-based ingredients.
  • Pleasant scent keeps your dog feeling refreshed.
  • Scientifically proven for reliable long-lasting protection.
  • Proudly manufactured in the USA for quality assurance.
  • Average Rating out of 5:
  • Price Range: $12.52
  • Size: 32 oz
  • Color: Green
8

FRONTLINE Plus Flea & Tick Treatment (3 Ct)

  • Fast-acting, waterproof flea and tick treatment.
  • Kills fleas, larvae, ticks, and chewing lice.
  • Prevents flea life cycle and further infestations.
  • Safe for puppies from eight weeks old.
  • Easy monthly application for consistent protection.
  • Available for both dogs and cats.
  • Subscribe & save for year-round protection.
  • Average Rating out of 5:
  • Price Range: $39.98
  • Size: 3 Count
  • Color: Blacks & Grays
9

K9 Advantix II Flea & Tick Treatment [2-Mo Supply]

  • Vet-recommended for effective flea and tick control.
  • Designed for medium dogs 11-20 lbs.
  • Kills fleas within 12 hours of application.
  • Repels mosquitoes, biting flies, and lice.
  • Easy, waterproof topical application after 24 hours.
  • Fragrance-free formula for sensitive dogs.
  • No prescription needed for purchase.
  • Average Rating out of 5:
  • Price Range: $29.98
  • Size: 2 Pack
  • Color: Medium Dog only
10

Adams Plus Flea & Tick Shampoo [24 Oz]

  • Kills adult fleas and flea eggs effectively.
  • Eliminates ticks on contact for quick relief.
  • Also kills lice to protect your pets.
  • Gentle formula ideal for sensitive skin types.
  • Conditions fur, leaving it shiny and soft.
  • Fresh scent keeps pets smelling delightful.
  • Economical use, only 1⅓ tablespoons needed.
  • Average Rating out of 5:
  • Price Range: $15.96
  • Size: 24 Ounces
11

Amazon Basics Flea & Tick Treatment (6 Doses)

  • Fast-acting relief within 24 hours of application.
  • Lasts up to 30 days for ongoing protection.
  • Targets fleas, ticks, eggs, and other pests.
  • Designed for large dogs weighing 45-88 pounds.
  • Contains effective ingredients: Fipronil and (s)-methoprene.
  • Previously branded as Solimo, same quality product.
  • Packaging may vary, formulation remains unchanged.
  • Average Rating out of 5:
  • Price Range: $27.95
  • Size: 6 Count
12

Wondercide Flea & Tick Spray [16 oz]

  • Kills and repels fleas, ticks, and mosquitoes.
  • Natural essential oils ensure safe application.
  • Effective for pets and home environments.
  • Safe for dogs and cats of all ages.
  • Fresh lemongrass scent invigorates your home.
  • Breaks flea life cycle effectively.
  • Cruelty-free and made in the USA.
  • Average Rating out of 5:
  • Price Range: $26.99
  • Size: 16 OZ
  • Color: Lemongrass
13

Amazon Basics Flea and Tick Treatment (6 Count)

  • Same effective formula as previous Solimo brand.
  • Targets fleas, ticks, and other pests quickly.
  • One application lasts up to 30 days.
  • Waterproof after 24 hours of application.
  • Suitable for small dogs (5 - 22 pounds).
  • Six doses in one convenient pack.
  • Unscented formula for sensitive pets.
  • Average Rating out of 5:
  • Price Range: $26.18
  • Size: 6 Count
14

Vet's Best Flea and Tick Spray [32 oz]

  • Protects yards from fleas, ticks, and mosquitoes.
  • Easy application with ready-to-use hose attachment.
  • Safe for plants and outdoor surfaces.
  • Uses certified natural plant-based ingredients.
  • Scientifically proven to kill and repel pests.
  • Manufactured in the USA for quality assurance.
  • Long-lasting flea and tick control for dogs.
  • Average Rating out of 5:
  • Price Range: $16.97
  • Size: 32 oz
  • Color: Whites & Tans
15

Adams Flea & Tick Home Spray [24 Fl Oz]

  • Effectively kills fleas, ticks, and bed bugs.
  • Fast action, starts working in 5 minutes.
  • Prevents new infestations for lasting protection.
  • Up to 7 months of effective flea control.
  • Safe for carpets, rugs, and upholstery use.
  • Fragrance-free, dries quickly without stains.
  • Easy to apply with controlled spray pattern.
  • Average Rating out of 5:
  • Price Range: $14.46
  • Size: 24 Ounces
  • Color: Blue
16

Frontline Plus Flea & Tick Treatment [3 Treatments]

  • Fast-acting flea and tick treatment for dogs.
  • Proven to kill fleas, larvae, and ticks.
  • Waterproof formula for lasting protection.
  • Breaks the flea life cycle effectively.
  • Easy monthly application for convenience.
  • Safe for puppies over eight weeks old.
  • Subscribe & save for year-round protection.
  • Average Rating out of 5:
  • Price Range: $39.98
  • Size: 3 Count
  • Color: Red Box
17

K9 Advantix II Flea & Tick Treatment [2-Mo]

  • Vet-recommended for effective flea and tick prevention.
  • Designed for dogs weighing 4-10 lbs.
  • Kills fleas within 12 hours of application.
  • Repels mosquitoes, biting flies, and lice.
  • Easy-to-apply topical treatment, fragrance-free.
  • Waterproof after 24 hours for lasting protection.
  • No prescription required for purchase.
  • Average Rating out of 5:
  • Price Range: $35.68
  • Size: 2 Pack
  • Color: Small Dog only
18

Advecta Ultra Flea and Tick Prevention (4 Month)

  • Breaks flea life cycle effectively and efficiently.
  • Kills fleas, eggs, and larvae in all stages.
  • Active ingredients match Bayer K9 Advantix II.
  • Eliminates fleas and lice within 12 hours.
  • Prevents reinfestations for up to 4 months.
  • Offers 5-way protection for your dog.
  • Waterproof formula remains effective even when wet.
  • Average Rating out of 5:
  • Price Range: $24.98
  • Size: 4 Dose
  • Color: Purple
19

Advantus Chewable Flea Treatment for Dogs [7 ct.]

  • Effective flea treatment for dogs and puppies.
  • Kills adult fleas within one hour.
  • Soft, flavored chew for easy administration.
  • For dogs weighing 23 - 110 lbs.
  • Can be given daily if re-infested.
  • No prescription needed for purchase.
  • Also available for smaller dogs (4-22 lbs).
  • Average Rating out of 5:
  • Price Range: $31.99
  • Size: 7 Count
20

Vet Treat Flea and Tick Chews (120 Soft Treats)

  • Natural flea and tick prevention for dogs.
  • Contains skin and coat support ingredients.
  • Made in USA with quality standards.
  • Vet recommended for safety and effectiveness.
  • Tasty chicken flavor dogs love.
  • Safe for all breeds and sizes.
  • No harmful chemicals or garlic included.
  • Average Rating out of 5:
  • Price Range: $19.95
  • Size: 120 Soft Chews
21

Hartz UltraGuard Flea & Tick Treatment (6ct)

  • Kills fleas, ticks, and their eggs on contact.
  • Prevents re-infestation for up to 30 days.
  • Fast-acting formula for full body protection.
  • Contains 6 monthly treatments for continuous protection.
  • Easy application at the base of the back.
  • For dogs weighing 5-14 pounds only.
  • Provides long-lasting flea and tick prevention.
  • Average Rating out of 5:
  • Price Range: $11.64
  • Size: 5-14 Pounds
  • Color: 6 Count
22

Vet's Best Flea and Tick Dog Shampoo [12 oz]

  • Effectively eliminates fleas, ticks, and larvae.
  • Safe for dogs 12 weeks and older.
  • Made with certified natural ingredients.
  • Features rosemary and peppermint oil benefits.
  • Veterinarian formulated for optimal pet care.
  • Provides double the flea fighting power.
  • Manufactured in the USA with quality ingredients.
  • Average Rating out of 5:
  • Price Range: $13.69
  • Size: 12 oz
23

PetArmor Flea and Tick Treatment for Large Dogs

  • Kills fleas, ticks, and chewing lice effectively.
  • Contains vet-quality fipronil for powerful protection.
  • Fast-acting formula stops infestations quickly.
  • Prevents brown dog ticks and Lyme disease transmission.
  • Includes three-month supply for continuous protection.
  • Easy application between shoulder blades on dry skin.
  • Backed by PetArmor Protection Guarantee for confidence.
  • Average Rating out of 5:
  • Price Range: $14.40
24

NEXTSTAR Flea and Tick Drops [3 Monthly]

  • Fast-acting protection against fleas and ticks.
  • Veterinarian recommended for optimal pet safety.
  • 7-way pest protection for comprehensive defense.
  • Waterproof formula for lasting effectiveness.
  • Easy application directly onto pet's skin.
  • Starts working within 15 minutes.
  • Customer support for your satisfaction guaranteed.
  • Average Rating out of 5:
  • Price Range: $34.99
  • Size: 3 Dose
25

YUMA'S Flea & Tick Chewables [170 Treats]

  • Natural flea and tick prevention for dogs.
  • 170 soft chewable treats for easy administration.
  • Suitable for all breeds and ages of dogs.
  • Veterinarian formulated for optimal safety and efficacy.
  • Made in USA in an FDA-registered facility.
  • Chicken-flavored for a tasty, hassle-free experience.
  • Daily administration ensures effective protection levels.
  • Average Rating out of 5:
  • Price Range: $23.97
  • Size: 170 Chews
  • Color: Brown
26

TropiClean Max Strength Flea & Tick Shampoo

  • Tough on fleas and ticks in one wash.
  • Natural ingredients ensure pet safety and care.
  • Lemongrass oil provides long-lasting pest repellent.
  • Fresh citrus scent leaves your dog smelling great.
  • Safe around kids, pets, home, and yard.
  • Pair with home spray for complete protection.
  • Made in the USA for quality assurance.
  • Average Rating out of 5:
  • Price Range: $16.99
  • Size: 20 oz
  • Color: Maximum Strength
27

Amazon Basics Flea & Tick Treatment (6 Count)

  • Effective for extra-large dogs over 55 pounds.
  • Eliminates fleas, ticks, and mosquitoes swiftly.
  • Kills flea eggs, larvae, and biting flies.
  • One application lasts up to 30 days.
  • Waterproof within 24 hours after application.
  • Same formulation as the previous Solimo brand.
  • No expiration date for product effectiveness.
  • Average Rating out of 5:
  • Price Range: $34.99
  • Size: 6 Count
28

Amazon Basics Flea and Tick Treatment (3 Count)

  • Fast-acting relief from fleas and ticks.
  • Waterproof within 24 hours of application.
  • Lasts up to 30 days of protection.
  • Kills fleas, ticks, lice, and their eggs.
  • Targets deer ticks to prevent Lyme disease.
  • Simple monthly application for medium dogs.
  • Same formula, new packaging as Solimo brand.
  • Average Rating out of 5:
  • Price Range: $17.45
  • Size: 3 Count
29

Amazon Basics Flea and Tick Treatment (6 Count)

  • Eliminates fleas and ticks within 24 hours.
  • Active ingredients: Fipronil and (s)-methoprene.
  • Prevents flea infestations by killing eggs and larvae.
  • One application lasts up to 30 days.
  • Waterproof protection after 24 hours of application.
  • Available in Solimo or Amazon Basics packaging.
  • For medium dogs weighing 23-44 pounds.
  • Average Rating out of 5:
  • Price Range: $27.95
  • Size: 6 Count